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Vanillin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vanillin图片
CAS NO:121-33-5
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
香草醛
FEMA 3107
p-Hydroxy-m-methoxybenzaldehyde
Zimco
m-Methoxy-p-hydroxybenzaldehyde
香兰素
p-Vanillin
Lioxin
产品介绍
Vanillin 是一种天然产物,是从香草豆中提取的单个分子,是香水,食品和药物中广泛使用的气味。

产品描述

Vanillin is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.Vanillin can reversibly and non-competitively inhibit the cellulase activity at appropriate concentrations and the value of IC50 was estimated to be 30 g/L.Vanillin protects KSC from UVB irradiation and its effects may occur through the suppression of downstream step of MDM2 in UVB irradiation-induced p53 activation. Vanillin also inhibits yeast growth and fermentation.

体内活性

The Vanillin with LD50 by oral is 1.58 g/ kg, 1.40 g/kg, 3.0 g/kg for rats,guinea pigs, rabbits,respectively.Several studies of oral toxicity in rats have reported that Vanillin is consumed in many cycles without side effects.

激酶实验

Ligand Binding Assay: To determine the binding affinity of T0070907 to the PPARs, scintillation proximity assay (SPA) is performed with the following modifications. A 90-μl reaction contains SPA buffer (10 mm KH2PO4, 10 mm KH2PO4, 2 mm EDTA, 50 mm NaCl, 1 mm dithiothreitol, 2 mmCHAPS, 10% (v/v) glycerol, pH 7.1), 50 ng of GST-PPARγ (or 150 ng of GST-PPARα, GST-PPARδ), 5 nm 3H-labeled radioligands, and 5 μl of T0070907 in Me2SO. After incubation for 1 h at room temperature, 10 μl of polylysine-coated SPA beads (at 20 mg/ml in SPA buffer) are added, and the mixtureis incubated for 1 h before reading in Packard Topcount. [3H]Rosiglitazone is used for PPARγ, and [3H]GW2433 is used for PPARα and PPARδ.

Cas No.

121-33-5

分子式

C8H8O3

分子量

152.149

别名

香草醛;FEMA 3107;p-Hydroxy-m-methoxybenzaldehyde;Zimco;m-Methoxy-p-hydroxybenzaldehyde;香兰素;p-Vanillin;Lioxin

储存和溶解度

DMSO:28 mg/mL (184 mM)
Ethanol:28 mg/mL (184 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years