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K-Ras ligand-Linker Conjugate 3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
K-Ras ligand-Linker Conjugate 3图片
CAS NO:2378261-87-9
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品介绍

产品描述

K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be used in the synthesis of PROTAC K-Ras Degrader-1, which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

体外活性

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Cas No.

2378261-87-9

分子式

C49H65N7O10S

分子量

944.15

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years