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Glycyrrhetic acid 3-O-β-D-glucuronide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Glycyrrhetic acid 3-O-β-D-glucuronide图片
CAS NO:34096-83-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Glycyrrhetic acid 3-O-β-D-glucuronide 是从甘草中分离出的甘草酸 3-O-β-D-葡萄糖醛酸，具有抗过敏活性，它是的甘草甜素 (GL) 的重要衍生物。 Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) 表明 β-葡糖醛酸糖苷酶 (β‐GUS)，它的关键的 GAMG 产生酶，可以将 GL 直接转化为 GAMG。 Glycyrrhetic acid 3-O-β-D-glucuronide 可作为甜味剂。
Cas No.34096-83-8
别名单葡萄糖醛酸甘草次酸
Canonical SMILESC[C@@]1([C@@]2([H])[C@@]3([C@@](C(C)([C@@H](O[C@]4([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)CC3)C)([H])CC1)C)[C@]5(C([C@@]6([H])[C@](C)(CC[C@@](C(O)=O)(C)C6)CC5)=CC2=O)C
分子式C36H54O10
分子量646.81
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity[1]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β‐glucuronidases (β‐GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG[2].Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

Glycyrrhetic acid 3-O-β-D-glucuronide can inhibit the release of β‐hexosaminidase from RBL‐2H3 cells with an IC50 value of 0.28 mM[2].Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) significantly reduces the nitrite concentration in a dose-dependent manner with an IC50 value of 120 μM in LPS‐induced RAW264.7 cells[2].

[1]. Park HY,et al. Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.Arch Pharm Res. 2004 Jan;27(1):57-60. [2]. Lichun Guo,et al. Glycyrrhetic Acid 3‐O‐Mono‐β‐d‐glucuronide (GAMG): An Innovative High‐Potency Sweetener with Improved Biological Activities. Comprehensive Reviews in Food Science and Food Safety