Lenalidomide-propargyl-C2-NH2 hydrochloride

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包装与价格：

产品介绍

Lenalidomide-propargyl-C2-NH2 hydrochloride 结合了 E3 泛素连接酶的配体 cereblon (CRBN) 和一个连接桥。Lenalidomide-propargyl-C2-NH2 hydrochloride 可用于设计 PROTAC MD-224.

Canonical SMILES	O=C(C(N(CC1=C2C=CC=C1C#CCCCN)C2=O)CC3)NC3=O.Cl
分子式	C₁₈H₂₀ClN₃O₃
分子量	361.82
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 [1]. [1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466.