SPD304 dihydrochloride 是 TNF-α 的特异性抑制剂，IC50 为 22 μM。 SPD304 dihydrochloride 促进 TNF 三聚体的解离。

SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 μM. SPD304 dihydrochloride promotes dissociation of TNF trimers.

The survivability of aHSCs is significantly rescued by SPD304 dihydrochloride (2 μM). The production of lipid hydroxides and intracellular GSH are increased as well. GA (75 μM) and SPD304 dihydrochloride (2 μM) downregulate TRADD (almost 2-fold) and p–RIP3 (1.4–fold) compared to GA and promote the activation of caspase 8[4].

1049741-03-8

C32H34Cl2F3N3O2

620.53

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years