GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).

GRKs-IN-1 hydrochloride (Compound 14as) is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine.

T13714L

C24H26ClFN4O4

488.94

GRK2-IN-1 hydrochloride

DMSO:250 mg/mL (511.31 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years