Elagolix是口服具有活性的、选择性高的非肽类促性腺激素释放激素受体短期有效拮抗剂 (KD = 54 pM)。

(R)-Elagolix is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a dose-dependent suppression of ovarian estrogen production, that is, from partial suppression at lower doses to full suppression at higher doses.

834153-87-6

C32H30F5N3O5

631.59

恶拉戈利;NBI-56418

DMSO:100 mg/mL (158.33 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years