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3-O-Methylquercetin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3-O-Methylquercetin图片
CAS NO:1486-70-0
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
25 mg电议
100 mg电议

产品介绍
3-O-Methylquercetin 是分离自植物Rhamnus nakaharai的天然产物,可抑制总 cAMP 和cGMP-phosphodiesteRase (PDE)。它对PDE1、PDE5、PDE 和PDE4的IC50分别是31.9 μM、86.9 μM、18.6 μM 和1.6 μM。

产品描述

3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low Km value. 3-O-Methylquercetin inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.

体外活性

Formulations composed of octyldodecanol, egg lecithin, water (NE) and cetyl trimethyl ammonium bromide (CNE) were obtained by spontaneous emulsification. This procedure yielded monodisperse nanoemulsions exhibiting a mean droplet size of approximately 200-300 nm. Nanoemulsions were further characterized in terms of zeta-potential, surface tension, and morphology by transmission electron microscopy. The amount of flavonoids incorporated into nanoemulsions reached nearly 100% (at 1 mg/mL). The permeation studies were carried out using ear pig skin mounted in Franz diffusion cells[1]

Cas No.

1486-70-0

分子式

C16H12O7

分子量

316.26

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years