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5-Hydroxy-1-methylhydantoin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-Hydroxy-1-methylhydantoin图片
CAS NO:84210-26-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
5-羟基-1-甲基咪唑啉-2,4-二酮
NZ 419
HD-003
HD003
NZ419
HD 003
NZ-419
产品介绍
5-Hydroxy-1-methylhydantoin 是一种可能用于治疗肾衰竭的抗氧化剂。它是肌酐代谢物,是一种羟基自由基清除剂,此前已显示通过抑制大鼠慢性肾病的进展来提供肾脏保护。 它是一种新型抗氧化药物,可完全抑制 B2-激肽受体 (B2KR) 对 VSMC 中高葡萄糖 (25 mM) 刺激的反应,并且还显示可减弱 BK 对 VSMC 重塑的影响。它抑制 BK 诱导的 MAPK 磷酸化增加并减弱 VSMC 中结缔组织生长因子 (CTGF) 蛋白水平的增加。这些研究结果表明,它可能通过其抗氧化特性赋予血管保护免受高葡萄糖浓度和 BK 刺激以改善血管损伤和重塑。

产品描述

NZ-419 is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, NZ-419, a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. NZ-419 a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. NZ-419 inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that NZ-419 may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

Cas No.

84210-26-4

分子式

C4H6N2O3

分子量

130.1

别名

5-羟基-1-甲基咪唑啉-2,4-二酮;NZ 419;HD-003;HD003;NZ419;HD 003;NZ-419

储存和溶解度

DMSO:60 mg/ml (525.85 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years