Pregnenolone acetate 是一种强大的神经类固醇，是各种类固醇激素（包括类固醇酮）的主要前体。它作为大麻素 CB1 受体的信号特异性抑制剂，抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。它可以保护大脑免受大麻中毒。

Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. It can protect the brain from cannabis intoxication

Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy[1].

Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones.?It acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. It?can protect the brain from cannabis intoxication[1].

1778-02-5

C23H34O3

358.522

孕烯醇酮醋酸酯;3β-Hydroxy-5-pregnen-20-one acetate

H2O:Insoluble
DMSO:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years