Sigma-1 receptor antagonist 1 是一种有效、特异性的 sigma-1 受体拮抗剂。 Sigma-1 receptor antagonist 1 具有抗神经性疼痛活性，可用于治疗神经性疼痛研究。

Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies.

Sigma-1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor with Ki of 1.06 nM and good σ-1/2 selectivity (1344-fold)[1].

In mice formalin model and rats CCI models of neuropathic pain, Sigma-1 receptor antagonist 1 exerts dose-dependent antinociceptive effects[1].

1639220-19-1

C19H23Cl2N3O

380.31

DMSO:6 mg/mL (15.78 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years