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Biotin-PEG4-amino-t-Bu-DADPS-C6-azide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Biotin-PEG4-amino-t-Bu-DADPS-C6-azide图片
CAS NO:1260247-50-4
包装:25mg
市场价:5400元

产品介绍
Biotin-PEG4-amino-t-Bu-DADPS-C6-azide是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
Cas No.1260247-50-4
别名DADPS叠氮生物素
Canonical SMILESO=C(NCC(C)(O[Si](C1=CC=CC=C1)(OCCCCCCN=[N+]=[N-])C2=CC=CC=C2)C)CCOCCOCCOCCOCCNC(CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O)=O
分子式C43H67N7O9SSi
分子量886.18
溶解度DMSO: 100 mg/mL (112.84 mM)
储存条件-20°, protect from light,unstable in solution, ready to use.
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562