| CAS NO: | 1365655-91-9 |
| 包装: | 100mg |
| 市场价: | 1350元 |
| Cas No. | 1365655-91-9 |
| 别名 | N-叔丁氧羰基-二聚乙二醇-羧酸 |
| Canonical SMILES | CC(C)(C)OC(NCCOCCOCCC(O)=O)=O |
| 分子式 | C12H23NO6 |
| 分子量 | 277.31 |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. [1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466. |
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