Urotensin I acetate 是一种 CRF 样神经肽，可作为 CRF 受体激动剂，对 CHO 细胞中的人 CRF1、人 CRF2 和大鼠 CRF2α 受体的 pEC50 分别为 11.46、9.36 和 9.85，对 CHO 细胞的 Kis 分别为 0.4、1.8 和 5.7 nM hCRF1、rCRF2α 和 mCRF2β 受体分别为。

Urotensin I acetate, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively[1][2].

Urotensin I acetate is 2-3 times more potent than CRF or sauvagine in stimulating ACTH release from a superfused goldfish anterior pituitary cell column[3]. Rat tail artery strips were incubated in the presence of 4 x 10(-3) M theophylline and Urotensin I acetate. At the concentrations of 1.50, 7.50 mU/ml but not of 0.75 mU/ml Urotensin I acetate, the content of cAMP increased significantly[4].

Intraperitoneal injections of urotensin I acetate, a CRF-like neuropeptide isolated from the caudal neurosecretory system of the teleost Catostomus commersoni, ovine CRF and sauvagine all produced significant increases in circulating levels of plasma cortisol in goldfish in which endogenous ACTH secretion was suppressed with betamethasone[3]

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years