Urocortin, human 是由 40 个氨基酸组成的神经多肽，是选择性CRF2受体激动剂，作用于 hCRF1(Ki:0.4 nM)、rCRF2α(Ki:0.3 nM)、 mCRF2β(Ki:0.5 nM)。

Urocortin (Ucn) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF).

Urocortin, human is a selective agonist of CRF2?receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF2α?and mouse CRF2β?receptors in cell assay, respectively[1].

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. It appears to be a more potent suppressor of ingestive behavior. Urocortin has the potential of inducing anxiogenic behavior[2].

176591-49-4

C204H337N63O64

4696.32

Human urocortin;Urocortin (human);Human urocortin I;Human urocortin 1

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years