Verucerfont 是促肾上腺皮质激素释放因子受体 1 (CRF1) 拮抗剂，作用于 CRF1(IC50:6.1 nM)，CRF2 (IC50>1000 nM)和 CRF-BP (IC50>1000 nM)。

Verucerfont is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .

Verucerfont potently blocked the HPA axis response to the dexamethasone-CRF test, but left alcohol craving unaffected.?Right amygdala responses to negative affective stimuli were significantly attenuated by verucerfont, but responses to alcohol-associated stimuli were increased in some brain regions, including left insula[1].

885220-61-1

C22H26N6O2

406.49

3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1,2,4-恶二唑-5-基)丙基]吡唑并[1,5-A]嘧啶-7-胺;GSK561679;NBI77860

DMSO:86.7 mg/mL (213.29 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years