Strontium Ranelate 是抗骨质疏松的药物,能够抑制骨吸收,促进骨形成,进而促使正骨平衡。它还能够激活非骨骼细胞中的钙敏感受体 (CaSR),进而促进肌醇 1,4,5-三磷酸的生成及丝裂原活化的蛋白激酶信号转导。
产品描述
Strontium ranelate, a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a "dual action bone agent" (DABA) indicated for use in the treatment of severe osteoporosis.
Cas No.
135459-87-9
分子式
C12H6N2O8SSr2
分子量
513.49
别名
Distrontium renelate;S12911;雷尼酸锶
储存和溶解度
H2O:Insoluble
DMSO:5.13 mg/ml (10 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years