ML314 is an effective molecule agonist of NTR1 (EC50: 1.9 μM).

ML314 showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway.

1448895-09-7

C24H28N4O3

420.5

DMSO:45 mg/mL (107.01 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years