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AF38469
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AF38469图片
CAS NO:1531634-31-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
AF-38469
产品介绍
AF38469 是一种新型、特异性和可口服的Sortilin抑制剂,IC50值为 330 nM。

产品描述

AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).

体外活性

AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition, AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate the evaluation of the therapeutic potential of this protein.

Cas No.

1531634-31-7

分子式

C15H11F3N2O3

分子量

324.25

别名

AF-38469

储存和溶解度

DMSO:40 mg/mL (123.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years