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CCG-50014
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CCG-50014图片
CAS NO:883050-24-6
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CCG 50014
4-[(4-氟苯基)甲基]-2-(4-甲基苯基)-1,2,4-噻二唑烷-3,5-二酮
产品介绍
CCG 50014 是一种有效的选择性 RGS4 抑制剂,IC50 为 30 nM。它在小鼠福尔马林试验中减少伤害性反应并增强阿片类药物介导减缓疼痛的作用。它与 RGS 共价结合,在位于变构调节位点的两个半胱氨酸残基上形成加合物。

产品描述

CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

体外活性

CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys?). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4?Gαo protein?protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. [1] [2]

Cas No.

883050-24-6

分子式

C16H13FN2O2S

分子量

316.35

别名

CCG 50014;4-[(4-氟苯基)甲基]-2-(4-甲基苯基)-1,2,4-噻二唑烷-3,5-二酮

储存和溶解度

DMSO:59 mg/mL (186.5 mM)
Ethanol:<1 mgml
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years