| CAS NO: | 1335282-05-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 1335282-05-7 |
| 别名 | CN328 |
| Canonical SMILES | CC1=C(O)C(O)=CC=[N+]1[C@H](CC2=CC=CC=C2)CO.[Cl-] |
| 分子式 | C15H18ClNO3 |
| 分子量 | 295.76 |
| 溶解度 | Methanol: 5mg/mL,Methanol:PBS (pH 7.2) (1:1): 0.5mg/mL |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CN128 is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1]. CN128 possesses a high selectivity for iron(III) over others metals[1]. CN128 (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].The iron removal efficacies of CN128 displays a dose-dependent behavior[1].CN128 lacks genetic toxicity[1].CN128 (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].CN128 is well-tolerated, with no mortality being observed at the higher dose levels in rats[1]. Animal Model: Male SD rats (300 g)[1] [1]. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226. |
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