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7-Octynoic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
7-Octynoic acid图片
CAS NO:10297-09-3
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
7-Octynoicacid(compound42)是一种PROTAClinker。7-Octynoicacid可用于合成一系列PROTAC分子。PROTAC分子含有两个通过linker连接的不同配体;一种是E3泛素连接酶配体,另一种是靶蛋白配体。PROTAC利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。
Cas No.10297-09-3
别名7-辛酸
Canonical SMILESC#CCCCCCC(O)=O
分子式C8H12O2
分子量140.18
溶解度DMSO: 150 mg/mL (1070.05 mM); Water: 5 mg/mL (35.67 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17.