IRL 2500 是内皮素受体的拮抗剂，对内皮素 A 受体和内皮素 B 受体的 IC50 分别为 1.3 和 94 nM。

IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.

In the anesthetized rat, IRL 2500 (10 mg/kg; i.v.) decreases the IRL 1620-mediated enhances renal vascular resistance. IRL 2500 suppresses the initial transient reduction in mean arterial pressure induced by IRL 1620[1]. IRL 2500 (10 mg/kg; i.v.) pre-treatment reduces the initial vasodepressor response to endothelin-1 and IRL 1620 without altering the secondary and sustained pressor response[2].

169545-27-1

C36H35N3O4

573.68

DMSO:93.6mg/mL (163.2mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years