Ro 46-844 是选择性非肽内皮素受体拮抗剂。它对ETB(IC50: 34-69 nM) 的选择性比ETA受体 (IC50: 6800 nM) 高的100倍以上。

RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.

175556-12-4

C31H35N3O8S

609.69

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years