Amiselimod hydrochloride 是一种鞘氨醇 1-磷酸受体 1 (S1P1) 调节剂。

Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.

After oral administration of amiselimod or fingolimod at 1 mg/kg, the concentration of amiselimod-P in rat heart tissue was relatively lower than that of fingolimod-P, potentially contributing to the minimal cardiac effects of amiselimod. Amiselimod-P showed potent selectivity for S1P1, high selectivity for S1P5, minimal agonist activity for S1P4, no distinct agonist activity for S1P2 or S1P3, and approximately 5-fold weaker GIRK activation than fingolimod-P [1]. Amiselimod 0·2 mg and 0·4 mg significantly reduced the total number of gadolinium-enhanced T1-weighted lesions [2].

942398-84-7

C19H31ClF3NO3

413.9

MT-1303 hydrochloride

DMSO:27mg/ml (65.23 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years