您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > TASIN-1 Hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
TASIN-1 Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TASIN-1 Hydrochloride图片
CAS NO:1678515-13-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
TASIN 1 HCl
TASIN-1 HCl
塔辛-1盐酸盐
TASIN1 HCl
产品介绍
TASIN-1 Hydrochloride 是一种截短型 APC 的选择性抑制剂,通过降低细胞胆固醇水平和通过结肠癌细胞中的 ER 应激/ROS/JNK 信号传导诱导凋亡细胞死亡来选择性杀死表达截短型 APC 的结肠直肠癌细胞。

产品描述

TASIN-1 Hydrochloride is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.

体内活性

In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1].

Cas No.

1678515-13-3

分子式

C18H29ClN2O3S

分子量

388.95

别名

TASIN 1 HCl;TASIN-1 HCl;塔辛-1盐酸盐;TASIN1 HCl

储存和溶解度

DMSO:55 mg/ml (141.41 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years