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DPTIP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DPTIP图片
CAS NO:351353-48-5
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
DPTIP 是一种有效的脑渗透性中性鞘磷脂酶 2 (N-SMase 2) 抑制剂(外泌体抑制剂),IC50 为 30 nM。
Cas No.351353-48-5
Canonical SMILESCOC1=CC(C2=NC(C3=CC=CC=C3)=C(C4=CC=CS4)N2)=CC(OC)=C1O
分子式C21H18N2O3S
分子量378.45
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.

Rojas et al (2018) DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci.Rep. 8 17715 PMID:30531925