GDC0575 monohydrochloride 是一种有效的、选择性的细胞周期检查点激酶 1 (Chk1) 抑制剂，IC50 为 1.2?nM。 GDC-0575 特异性结合并抑制 Chk1；这可能导致肿瘤细胞在 S 期和 G2/M 期绕过 Chk1 依赖性细胞周期停滞，从而允许细胞在进入有丝分裂之前进行 DNA 修复。

GDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.

1196504-54-7

C16H21BrClN5O

414.73

ARRY-575;GDC-0575;GDC0575;ARRY575;GDC 0575

DMSO:60 mg/ml (144.67 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years