MKC9989 是一种羟基芳基醛 (HAA) 的抑制剂，抑制 IRE1α的IC50值在 0.23 到 44 μM 之间。

MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.

MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin.[1].

1338934-20-5

C17H20O7

336.34

DMSO:49 mg/mL (145.68 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years