Rhosin hydrochloride 是一种特异性 RhoA 亚家族Rho GTPases抑制剂，抑制 RhoA-GEF 相互作用。它通过增强 D1 中棘神经元的可塑性和降低过度兴奋性来促进应激恢复，可诱导细胞凋亡。

Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride causes cell apoptosis.

Rhosin hydrochloride causes decreased size and reduced number of mammospheres in MCF7 cells. Rhosin hydrochloride dose-dependently reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres (EC50: ~30-50 μM) [1].

1281870-42-5

C20H19ClN6O

394.86

DMSO:100 mg/mL (253.25 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years