T-00127_HEV1 是有效的phosphatidyliNOSitol 4-kinase III beta抑制剂，IC50为 60 nM。

T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta(PI4KIIIβ, IC50 = 60 nM).

T-00127_HEV1 displays a more potent anti-poliovirus activity (EC50: 0.77 μM) than other candidate compounds (EC50: 1.7 to 4.7 μM). GW5074 and T-00127_HEV1 almost fully inhibit PI4KB kinase activity at 10 μM (3% and 5% of residual activity, respectively), in contrast to AN-12-H5 (108% of activity [no inhibition]) [1].

900874-91-1

C22H29N5O3

411.5

DMSO:6 mg/ml (14.58 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years