Sodium 4-amiNOSalicylate dihydrate是一种抗耐药性结核化合物。

Aminosalicylate Sodium is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Aminosalicylate sodium exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death.

局部灌注7.5 mg/mL 4-aminosalicylate后,麻醉大鼠的肠道中出现N-乙酰基-5-氨基水杨酸.

4-Aminosalicylate具有有效的DPPH自由基清除剂活性。4-Aminosalicylate迅速清除水相中的氢过氧自由基,产生类似Trolox或半胱氨酸的的浓度依赖性周期,表明链断裂型抗氧化活性。4-Aminosalicylate(0.65 mM)减弱超氧自由基或过氧化氢对中国仓鼠卵巢细胞的致死作用。在培养的小鼠腹腔巨噬细胞中,Aminosalicylate (25 mM) 以时间-和浓度依赖的方式刺激磷脂酶D,4-aminosalicylate (5 mM)增强蛋白激酶C对PLD的激活作用。处理巨噬细胞后,4-aminosalicylate (20 mM)增加260%的肌醇1,4,5-三磷酸水平。在离体的结肠粘膜细胞中,4-aminosalicylate (0.1 mM)剂量相关性减少LTB4的合成,从而减少LTB4/PGE2比率。

6018-19-5

C7H6NNaO3·2H2O

211.15

Sodium 4-Aminosalicylate;4-Amino-salicylic acid sodium salt;对氨基水杨酸钠二水合物

H2O:198.9 mM
DMSO:198.9 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years