Ipriflavone 是一种合成异黄酮衍生物，可用于抑制骨吸收。

Ipriflavone (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption.

Ipriflavone可以明显抑制MDA-231异种移植的肿瘤生长,与对照组小鼠相比,治疗后的小鼠体积分别减少25%和45%,重量分别减少47%和63%,并延长荷瘤小鼠的寿命.对于骨转移癌,口服给药12 mg Ipriflavone明显抑制MDA-231细胞的新溶骨骨转移的发展,抑制溶骨性病变的进展,并减少临近癌细胞的破骨细胞数量.

通过增强某些重要基质蛋白的表达并促进矿化过程,Ipriflavone调节人骨髓基质骨祖细胞(BMC)的分化和生物合成。在培养的小鼠未分化骨细胞中,10 mM Ipriflavone明显抑制糖基化终产物增强的骨吸收。Ipriflavone在50 mM剂量下不会引起MDA-231细胞的凋亡。Ipriflavone剂量依赖性抑制MDA-231细胞的增殖和DNA合成,并阻断配体诱导的EGFR中Tyr845的磷酸化。

Cells are exposed to various concentrations of Ipriflavone for 24, 48, 72 and 96 hours. Cells are treated with trypan blue to estimate the number of viable cells. For thymidine incorporation analysis, [3H]Thymidine (1 μCi) is added, and cells are harvested onto glass fiber filters 4 hours later. Radioactivity is determined by scintillation counting.(Only for Reference)

35212-22-7

C18H16O3

280.32

依普黄酮;Osteofix

DMSO:52 mg/mL (185.5 mM)
Ethanol:2 mg/mL (7.13 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years