| 包装: | 5mg |
| 市场价: | 5483元 |
| Canonical SMILES | O=C(NC1CC1)C2=C(C3=C(N=C2)C=C(F)C(C4=CC(F)=C(C=C4)C(NCCCCN5N=NC(COC6=C(C7=CC=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=C5)=O)=C3)NC9=CC=CC=C9 |
| 分子式 | C46H39F2N9O7 |
| 分子量 | 867.85 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.34 nM; Dmax = 93.14%). Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below). (MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in - see protocol for more information.) 0 |
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