AZ12672857 是一种 EphB4 抑制剂，IC50 为 1.3 nM。 AZ12672857 抑制 Src 转染 3T3 细胞的细胞增殖，IC50 为 2 nM，抑制转染 CHO-K1 细胞中 EphB4 的自磷酸化，IC50 为 9 nM。

AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphorylation of EphB4 in transfected CHO-K1 cells with IC50 of 9 nM.

AZ12672857 shows IC50s of 240 nM and 58 nM for p-KDR in HUVEC and p-PDGFR-β in MG63 cell line. AZ12672857 moderately inhibits CYP P450 with IC50s of 5 μM for 2C9 and 3A4 and >10 μM for 1A4, 2D6 and 2C19[1].

945396-55-4

C26H30N8O2

486.57

DMSO:20 mg/mL (41.1 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years