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KCC 07
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KCC 07图片
CAS NO:315702-75-1
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
KCC 07 是一种有效的、选择性的和脑渗透性 MBD2(甲基-CpG 结合域蛋白 2)抑制剂。 KCC 07 阻止 MBD2 与甲基化 DNA 结合并激活脑特异性血管生成抑制剂 1 (BAI1),诱导抗增殖 BAI1/p53/p21 信号传导。抗癌活性。
Cas No.315702-75-1
Canonical SMILESOC1=CC=CC(NC2=NC(C3=CC=CC=N3)=CS2)=C1
分子式C14H11N3OS
分子量269.32
溶解度Soluble in DMSO
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.

Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID:29894688