WRG-28 是一种选择性的、细胞外作用的DDR2变构抑制剂 (IC50:230 nM)。它通过受体的变构调节特异地抑制受体-配体相互作用。它通过靶向 DDR2 抑制肿瘤侵袭和迁移，基质的肿瘤支持作用，能够抑制肺中的转移性乳腺肿瘤细胞定植。

WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)

WRG-28 is a selective, extracellularly acting small molecule inhibitor of DDR2 that uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor.?By targeting DDR2, WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs.

1913291-02-7

C21H18N2O5S

410.44

DMSO:15 mg/mL (36.55 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years