F-1 是 ALK 和 ROS1 的双重抑制剂，抑制 ALK 的磷酸化及下游通路，可作用于对 ALKWT (IC50:2.1 nM)，ROS1WT (IC50:2.3 nM)，ALKL1196M (IC50:1.3 nM) 和 ALKG1202R (IC50:3.9 nM)。

F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.

2244775-31-1

C22H27ClN8O3S

519.02

DMSO:100 mg/mL (192.67 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years