Bucladesine sodium salt 是一种选择性的PKA活化剂，是一种稳定的环 AMP (cAMP) 类似物，可提高细胞内 cAMP 的水平。它也是一种磷酸二酯抑制剂。它具有抗炎活性，可用于伤口愈合不良。

Bucladesine, PKA activator, is a cyclic nucleotide derivative that mimics the action of endogenous cAMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant.

In cultured rat hepatocytes, Bucladesine has the affection of inhibited of NF-κB-binding activity and inducible nitric oxide synthase expression. Bucladesine also inhibits TNFα-induced hepatocyte apoptosis by suppressing FADD up-regulation.

In a mouse model, bucladesine (600 nM, i.p.) reverses lead acetate- and zinc chloride-induced impairments of avoidance memory retention.

Animal: Mice. Formulation: water/DMSO (9:1). Dosages: 600 nM. Administration: i.p.

16980-89-5

C18H23N5NaO8P

491.373

Bucladesine;Sodium dibutyryl cAMP;DC2797;Dibutyryl-cAMP sodium salt;Dibutyryl-cAMP;布拉地新钠盐;Bucladesine sodium salt;dbcAMP

DMSO:49.1 mg/mL (100 mM)
H2O:49.1 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years