PF-562271 HCl 是一种可逆的，有效的，ATP 竞争性的 FAK (IC50:1.5 nM)和 PYK2 (IC50:13 nM)激酶抑制剂。

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

939791-41-0

C21H20F3N7O3S HCl

543.95

PF-562271 HCl

DMSO:91 mg/mL(167.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years