Demethylwedelolactone 是一种分离自Eclipta alba中的 coumestan 天然产物。它能抑制乳腺癌细胞的移动和侵袭，是一种有效的trypsin抑制剂(IC50:3.0 μM)。

Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.

demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells.?Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice.?DWEL derivatives exert anti-invasive growth effect on breast cancer cells.

6468-55-9

C15H8O7

300.22

去甲基蟛蜞内酯;去甲蟛蜞菊内酯

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years