TalaboSTAT mesylate 是一种具有口服活性和非选择性的二肽基肽酶 IV抑制剂(IC50< 4 nM;Ki= 0.18 nM)。TalaboSTAT mesylate是成纤维细胞活化蛋白的第一个临床抑制剂(IC50= 560 nM)，抑制 DPP8/9 (IC50= 4/11 nM;Ki= 1.5/0.76 nM)，静息细胞脯氨酸二肽酶(IC50= 310 nM)、DPP2 和一些其他 DASH 家族酶。TalaboSTAT mesylate具有抗肿瘤和造血刺激活性 。

Talabostat mesylate is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony-stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis.

150080-09-4

C10H23BN2O6S

310.17

Val-boroPro;PT100

DMSO:40 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years