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DBPR108
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DBPR108图片
CAS NO:1186426-66-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
DBPR108是新型、具有口服活性、选择性的DPP4抑制剂,IC50=为15nM,对DPP8和DPP9基本无抑制。

产品描述

DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.

体外活性

DBPR108 displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II.

体内活性

DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes mellitus. The in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated.

Cas No.

1186426-66-3

分子式

C16H25FN4O2

分子量

324.39

储存和溶解度

DMSO:≥ 25 mg/mL (77.07 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years