Oleuropein 在橄榄叶和油中发现的天然产物，通过 p53 依赖性途径以及Bax和BCL2基因的调控来诱导乳腺癌细胞凋亡，还抑制芳香化酶。它可通过直接抑制PPARγ转录活性来发挥抗氧化，抗炎和抗动脉粥样硬化作用。

Oleuropein is an antioxidant polyphenol isolated from olive leaf.

In both J774A.1 cells and primary mouse macrophages, Oleuropein increases LPS-induced NO production. [1] Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. [2] In TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells, Oleuropein inhibits cell proliferation and migration. [3]

In swiss albino mice that spontaneously develop soft tissue sarcomas, Oleuropein (i.p. or p.o.) completely regresses tumors. [3] In rats, Oleuropein (40 mg/kg, p.o.) protects from cardiac remodeling process after isoproterenol-induced myocardial infarction through inhibiting angiotensin-converting enzyme activity. [4]

32619-42-4

C25H32O13

540.518

橄榄苦苷;洋橄榄苦甙

Ethanol:93 mg/mL (172.1 mM)
H2O:92 mg/mL (170.2 mM)
DMSO:93 mg/mL (172.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years