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Olmesartan medoxomil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Olmesartan medoxomil图片
CAS NO:144689-63-4
包装与价格:
包装价格(元)
10 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
奥美沙坦酯
Benicar
CS 866
产品介绍
Olmesartan medoxomil 是血管紧张素 (angiotensin AT1) 受体选择性抑制剂(IC50:66.2 μM)。

产品描述

Olmesartan medoxomil is an angiotensin II type 1 receptor blocker that is used to manage hypertension.

体外活性

Olmesartan Medoxomil significantly reduces liver hydroxyproline content, the mRNA expression of collagen alpha1(I) and alpha-smooth muscle actin (alpha-SMA), and plasma levels of transforming growth factor-beta1 (TGF-beta1). [1] Olmesartan Medoxomil is a pro-drug containing an ester moiety that, after oral administration, is rapidly cleaved to release the active form Olmesartan (RNH-6270). Olmesartan is a highly potent, competitive and selective All AT1 receptor antagonist with almost no antagonistic activity on AT2 and AT4 receptors. [2]

体内活性

Olmesartan produces a rapid and long-lasting inhibition of All-induced pressor responses in conscious rats. Oralolmesartan medoxomil also inhibits All-pressor response but onset of the action is slower compared with intravenous administration. Olmesartan Medoxomil exhibits dose-dependent antihypertensive effects in several rat and dog models, with the most marked effects seen in high plasma renin models, when compared with normal or low renin types. Olmesartan medoxomil exhibits, beside antihypertensive effects, beneficial effects in animal models of various types of nephrosis and heart failure, and anti-atherogenic effects in hyperlipidaemic animals. [2] Olmesartan Medoxomil dose-dependently ameliorates the colonic histopathological and biochemical injuries in rats, an effect that is comparable or even better than that of the standard Sulfasalazine. [3] Olmesartan medoxomil significantly reduces the induction of hypoxic cor pulmonale not only on echocardiographical observations but also in brain natriuretic peptide (BNP) in chronic hypoxic rats, TGF-beta and endothelin gene expressions in molecular studies. [4]

Cas No.

144689-63-4

分子式

C29H30N6O6

分子量

558.595

别名

奥美沙坦酯;Benicar;CS 866

储存和溶解度

Ethanol:<1 mgml
H2O:<1 mgml
DMSO:82 mg/mL (146.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years