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Fmoc-Gly3-Val-Cit-PAB
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fmoc-Gly3-Val-Cit-PAB图片
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
Fmoc-Gly3-Val-Cit-PAB是一种可降解(cleavable)的ADClinker,可用于合成抗体偶联药物(ADC)。
Canonical SMILESOCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CNC(CNC(CNC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)=O)=O)=O)=O)=O
分子式C39H48N8O9
分子量772.85
溶解度DMSO: 100 mg/mL (129.39 mM); Water:< 0.1 mg/mL (insoluble)
储存条件4℃, stored under nitroge
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fmoc-Gly3-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.