α-Zearalenol 是一种霉菌毒素，对雌激素受体具有高亲和力。它是 zearalenone (ZEN) 的一种衍生物，由于其异种雌激素效应可引起动物的生殖障碍。

α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).

α-Zearalenol (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 μM α-ZOL exposure in MFC-7 cells (IC50: 12.5 μM) [1].α-Zearalenol (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells. It increases the MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells. α-Zearalenol (1-10 μM; 24 hours) reduces the expression of TNF-α, α-Zearalenol combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergically for IL-8 at high toxin concentrations [2].

36455-72-8

C18H24O5

320.38

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years