AH-7614 是一种选择性的游离脂肪酸受体 4 (FFA4/GPR120) 拮抗剂，对人和大小鼠 FFA4 的pIC50值分别为 7.1、8.1 和 8.1。它能够阻断多不饱和 ω-6 脂肪酸亚油酸和 FFA4 激动剂的作用。

AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.

AH7614 (0.063, 0.25, and 1μM) blocked linoleic acid and GSK137647A-induced intracellular calcium increase in U2OS osteosarcoma cells expressing the FFA4 receptor. In addition, the increase of glucose-stimulated insulin secretion by GSK137647A (50 μM) was abolished in the presence of the selective FFA4 antagonist AH7614 (100 μM) in the MIN6 mouse insulinoma cell line. Moreover, AH7614 (100 μM) blocked GSK137647A (100μM)-mediated a modest increase of GLP-1 secretion in the NCIH716 cells.

6326-06-3

C20H17NO3S

351.42

AH 7614

Ethanol:Insoluble
H2O:Insoluble
DMSO:35.1 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years