Pamoic acid 是GPR35激动剂 (EC50:79 nM) 。它拥有抗炎及神经保护特性。

Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.

pamoic acid induces a G(i/o)-linked, GPR35-mediated increase in the phosphorylation of extracellular signal-regulated kinase 1/2, recruitment of β-arrestin2 to GPR35, and internalization of GPR35. In mice,

130-85-8

C23H16O6

388.375

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years