CVN424 是一种有效的、具有口服活性的、选择性的GPR6反向激动剂，其EC50=9.4 nM，EC50=38 nM。它可以透过血脑屏障，对帕金森病具有潜在的研究价值。

CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.

CVN424 is brain-penetrant and shows dose-dependent receptor occupancy that attained brain 50% of receptor occupancy at plasma concentrations of 6.0 and 7.4 ng/ml in mice and rats, respectively[1].

2254706-21-1

C24H29F2N5O3

473.52

DMSO:60mg/mL (126.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years